Sulfonated RAFT copolymers as heparin mimetics: synthesis, reactivity ratios, and anticoagulant activity

Al Nahain, Abdullah, Ignjatovic, Vera, Monagle, Paul, Tsanaktsidis, John, Vamvounis, George, and Ferro, Vito (2020) Sulfonated RAFT copolymers as heparin mimetics: synthesis, reactivity ratios, and anticoagulant activity. Macromolecular Bioscience. 2000110. (In Press)

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Abstract

The glycosaminoglycan heparin is a clinically important anticoagulant drug, primarily used to reduce the risk of blood clots (thrombosis) during surgery. Despite its importance in medicine and its continuous use over many decades, heparin suffers from several limitations associated with its heterogeneity and its extraction from animal tissues. In order to address these limitations, reversible addition-fragmentation chain transfer polymerization is utilized to prepare a library of heparin mimetic copolymers from the sulfonated monomers sodium 4-styrene sulfonate, potassium-3-sulfopropyl acrylate, potassium-3-sulfopropyl methacrylate, and sodium-2-acrylamido-2-methyl-1-propane sulfonate. Copolymers are prepared using combinations of two different monomers in various ratios. Monomer reactivity ratios are also determined for some representative monomer combinations, and all polymers are characterized by 1H NMR spectroscopy and gel permeation chromatography. The anticoagulant activities of the copolymers are determined by activated partial thromboplastin time and thrombin clotting time assays and structure–activity relationships are explored.

Item ID: 63556
Item Type: Article (Research - C1)
ISSN: 1616-5195
Copyright Information: © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Funders: Australian Research Council (ARC)
Projects and Grants: ARC DP170104431
Date Deposited: 24 Jun 2020 22:43
FoR Codes: 03 CHEMICAL SCIENCES > 0303 Macromolecular and Materials Chemistry > 030399 Macromolecular and Materials Chemistry not elsewhere classified @ 50%
06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060199 Biochemistry and Cell Biology not elsewhere classified @ 50%
SEO Codes: 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100%
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