Baxter, Alan G., and Duckworth, Rowena C. (2004) Models of type I (autoimmune) diabetes. Drug Discovery Today: Disease Models, 1 (4). pp. 451-455.

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Abstract

Type 1 (autoimmune) diabetes is caused by T-cell autoreactivity resulting in destruction of the insulin-producing pancreatic islet β cells. Its aetiology involves complex interactions between multiple genetic and environmental factors, its pathogenesis involves interactions between many leukocyte subsets and their associated cytokines and its complications affect nearly every organ in the body. Modelling the disease is, therefore, the subject of much effort and surprising ingenuity. In this article, we review established and emerging models of the disease and give an indication of their use for different types of study.

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