Development, ontogeny, and maintenance of TCRab+ CD8aa IEL

Ruscher, Roland, and Hogquist, Kristin A. (2019) Development, ontogeny, and maintenance of TCRab+ CD8aa IEL. Current Opinion in Immunology, 58. pp. 83-88.

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Abstract

The intestinal epithelium is the outermost cellular layer that separates the body from the gut lumen. The integrity of this protective mucosal barrier is crucial and maintained by specialized cells—intraepithelial lymphocytes (IEL). Much research has been conducted on these cells and our overall understanding of them is increasing rapidly. In this review we focus on the TCRab+ subset of CD8aa IEL. We discuss recent studies that shed light on the development, ontogeny, maintenance, and functional characteristics of CD8aa IEL, and highlight yet unanswered questions for future studies.

Item ID: 60648
Item Type: Article (Research - C1)
ISSN: 1879-0372
Copyright Information: © 2019 Elsevier Ltd. All rights reserved.
Funders: National Institutes of Health (NIH)
Projects and Grants: NIH R37 AI39560
Date Deposited: 22 Oct 2019 04:10
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110704 Cellular Immunology @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 50%
97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 50%
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