Quan, Phenix-Lan, Wagner, Thor A., Briese, Thomas, Torgerson, Troy R., Hornig, Mady, Tashmukhamedova, Alla, Firth, Cadhla, Palacios, Gustavo, Baisre-De-Leon, Ada, Paddock, Christopher D., Hutchison, Stephen K., Egholm, Michael, Zaki, Sherif R., Goldman, James E., Ochs, Hans D., and Lipkin, W. Ian (2010) Astrovirus Encephalitis in Boy with X-linked Agammaglobulinemia. Emerging Infectious Diseases, 16 (6). pp. 918-925.

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Abstract

Encephalitis is a major cause of death worldwide. Although >100 pathogens have been identified as causative agents, the pathogen is not determined for up to 75% of cases. This diagnostic failure impedes effective treatment and underscores the need for better tools and new approaches for detecting novel pathogens or determining new manifestations of known pathogens. Although astroviruses are commonly associated with gastroenteritis, they have not been associated with central nervous system disease. Using unbiased pyrosequencing, we detected an astrovirus as the causative agent for encephalitis in a 15-year-old boy with agammaglobulinemia; several laboratories had failed to identify the agent. Our findings expand the spectrum of causative agents associated with encephalitis and highlight unbiased molecular technology as a valuable tool for differential diagnosis of unexplained disease.

Item ID:	59919
Item Type:	Article (Research - C1)
ISSN:	1080-6059
Copyright Information:	All materials published in Emerging Infectious Diseases, including text, figures, tables, and photographs, are in the public domain and can be reprinted or used without permission with proper citation. All content is freely available without charge to the user or their institution. In accordance with the Budapest Open Access InitiativeExternal Link definition of open access, users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. Because the journal is in the public domain, its usage policy also conforms to conditions set forth by Creative Commons.
Date Deposited:	01 Aug 2024 00:10
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110804 Medical Virology @ 25% 06 BIOLOGICAL SCIENCES > 0605 Microbiology > 060502 Infectious Agents @ 50% 06 BIOLOGICAL SCIENCES > 0605 Microbiology > 060503 Microbial Genetics @ 25%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 70% 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 30%
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