Quan, Phenix-Lan, Firth, Cadhla, Street, Craig, Henriquez, Jose A., Petrosov, Alexandra, Tashmukhamedova, Alla, Hutchison, Stephen K., Egholm, Michael, Osinubi, Modupe O.V., Niezgoda, Michael, Ogunkoya, Albert B., Briese, Thomas, Rupprecht, Charles E., and Lipkin, W. Ian (2010) Identification of a Severe Acute Respiratory Syndrome Coronavirus-Like Virus in a Leaf-Nosed Bat in Nigeria. mBio, 1 (4). e00208-e00210.

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Abstract

Bats are reservoirs for emerging zoonotic viruses that can have a profound impact on human and animal health, including lyssaviruses, filoviruses, paramyxoviruses, and severe acute respiratory syndrome coronaviruses (SARS-CoVs). In the course of a project focused on pathogen discovery in contexts where human-bat contact might facilitate more efficient interspecies transmission of viruses, we surveyed gastrointestinal tissue obtained from bats collected in caves in Nigeria that are frequented by humans. Coronavirus consensus PCR and unbiased high-throughput pyrosequencing revealed the presence of coronavirus sequences related to those of SARS-CoV in a Commerson's leaf-nosed bat (Hipposideros commersoni). Additional genomic sequencing indicated that this virus, unlike subgroup 2b CoVs, which includes SARS-CoV, is unique, comprising three overlapping open reading frames between the M and N genes and two conserved stem-loop II motifs. Phylogenetic analyses in conjunction with these features suggest that this virus represents a new subgroup within group 2 CoVs.

Item ID:	59916
Item Type:	Article (Research - C1)
ISSN:	2150-7511
Copyright Information:	© 2010 Quan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
Date Deposited:	31 Jul 2024 23:41
FoR Codes:	06 BIOLOGICAL SCIENCES > 0605 Microbiology > 060506 Virology @ 50% 06 BIOLOGICAL SCIENCES > 0604 Genetics > 060409 Molecular Evolution @ 50%
SEO Codes:	97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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