Koolpinyah and Yata viruses: two newly recognised ephemeroviruses from tropical regions of Australia and Africa

Blasdell, Kim R., Widen, Steven G., Diviney, Sinéad M., Firth, Cadhla, Wood, Thomas G., Guzman, Hilda, Holmes, Edward C., Tesh, Robert B., Vasilakis, Nikos, and Walker, Peter J. (2014) Koolpinyah and Yata viruses: two newly recognised ephemeroviruses from tropical regions of Australia and Africa. Veterinary Microbiology, 174 (3-4). pp. 547-553.

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Koolpinyah virus (KOOLV) isolated from healthy Australian cattle and Yata virus (YATV) isolated from a pool of Mansonia uniformis mosquitoes in the Central African Republic have been tentatively identified as rhabdoviruses. KOOLV was shown previously to be related antigenically to kotonkon virus, an ephemerovirus that has caused an ephemeral fever-like illness in cattle in Nigeria, but YATV failed to react antigenically with any other virus tested. Here we report the complete genome sequences of KOOLV (16,133 nt) and YATV (14,479 nt). Each has a complex genome organisation, with multiple genes, including a second non-structural glycoprotein (GNS) gene and a viroporin (α1) gene, between the G and L genes as is characteristic of ephemeroviruses. Based on an analysis of genome organisation, sequence identity and cross-neutralisation, we demonstrate that both KOOLV and YATV should be classified as two new species in the genus Ephemerovirus.

Item ID: 59906
Item Type: Article (Research - C1)
ISSN: 1873-2542
Funders: Institute for Human Infections and Immunity, National Institute of Health (NIH), USA, National Health and Medical Research Council of Australia (NHMRC)
Projects and Grants: NIH contract HHSN272201000040I/HHSN27200004/D04, NHMRC Fellowship AF30
Date Deposited: 11 Sep 2019 04:29
FoR Codes: 06 BIOLOGICAL SCIENCES > 0604 Genetics > 060409 Molecular Evolution @ 70%
06 BIOLOGICAL SCIENCES > 0605 Microbiology > 060506 Virology @ 30%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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