Evolutionary history of Simbu serogroup orthobunyaviruses in the Australian episystem

Wang, Jidong, Firth, Cadhla, Amos-Ritchie, Rachel, Davis, Steven S., Yin, Hong, Holmes, Edward C., Blasdell, Kim R., and Walker, Peter J. (2019) Evolutionary history of Simbu serogroup orthobunyaviruses in the Australian episystem. Virology, 535. pp. 32-44.

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Abstract

Orthobunyaviruses of the Simbu serogroup are transmitted by insects (primarily biting midges) and infect mammals and/or birds. Many have been associated with disease in livestock or humans. The orthobunyavirus genome comprises three negative-sense RNA segments (L, M and S). We report the complete coding sequences of 57 isolates of Simbu serogroup viruses collected in Australia during 1968–1984. Phylogenetic analysis identified novel genogroups of Akabane virus (AKAV), Aino virus (AINOV) and Peaton virus, and provided evidence of constrained movement of AKAV between epidemiological systems in the northern and eastern regions of the continent. Differential clustering of AKAV isolates in trees inferred from L, M and S segments was indicative of intratypic segment reassortment. Similarly, intertypic segment reassortment was detected between AKAV and Tinaroo virus, and between AINOV and Douglas virus. L segments representing novel genogroups were detected in AINOV reassortants, suggesting the presence of unidentified Simbu group viruses in the episystem.

Item ID: 59898
Item Type: Article (Research - C1)
ISSN: 1096-0341
Copyright Information: © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Funders: Chinese Scholarship Council (CSC), Australian Research Council (ARC)
Projects and Grants: ARC FL170100022
Date Deposited: 16 Sep 2019 00:16
FoR Codes: 06 BIOLOGICAL SCIENCES > 0604 Genetics > 060409 Molecular Evolution @ 40%
07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070712 Veterinary Virology @ 60%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences @ 100%
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