The pathology of 'scale drop syndrome' in Asian seabass, Lates calcarifer Bloch, a first description

Gibson-Kueh, S., Chee, D., Chen, J., Wang, Y. H., Tay, S., Leong, L. N., Ng, M. L., Jones, J. B., Nicholls, P. K., and Ferguson, H. W. (2012) The pathology of 'scale drop syndrome' in Asian seabass, Lates calcarifer Bloch, a first description. Journal of Fish Diseases, 35 (1). pp. 19-27.

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Abstract

This is the first pathological description of 'scale drop syndrome' (SDS) in Asian seabass, Lates calcarifer Bloch. Cumulative mortality was estimated at 40-50%. The vasculitis in all major organs including the skin and associated tissue necrosis was distinctive. The dermis overlying scale beds was often necrotic and associated with scale loss. Necrosis of splenic ellipsoids, renal glomeruli and choroid rete glands of eye were further hallmarks of a disease with systemic vascular involvement. The brain was not spared vascular damage, and the resulting multifocal encephalomalacia probably accounts for the spiral swimming behaviour in some affected fish. Other lesions included accentuated hepatic lobulation and gastric gland necrosis. Nuclear chromatin margination and karyolysis in hepatocytes, renal tubular epithelium and gastric and intestinal epithelium suggest specific targeting of cells. Basophilic cytoplasmic inclusions were present in spleen, kidney, liver, heart and choroid rete, but they were not prominent. Using transmission electron microscopy, two morphological forms of virions were observed: single- and double-enveloped hexagonal virions. Based on size and morphology, these virions resemble iridovirus or herpesvirus. The cause of SDS is unknown, but the pathological changes, especially the vasculitis, suggest an infectious aetiology, possibly viral. © 2011 Blackwell Publishing Ltd.

Item ID: 59123
Item Type: Article (Research - C1)
ISSN: 1365-2761
Keywords: Lates calcarifer, necrosis, scale loss, vasculitis, virus
Copyright Information: © 2011 Blackwell Publishing Ltd
Date Deposited: 26 Nov 2019 06:23
FoR Codes: 07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070709 Veterinary Pathology @ 50%
07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070703 Veterinary Diagnosis and Diagnostics @ 30%
07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070712 Veterinary Virology @ 20%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences @ 50%
97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 50%
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