Advances in functionalized polymer coatings on biodegradable magnesium alloys – a review

Li, Ling-Yu, Cui, Lan-Yue, Zeng, Rong-Chang, Li, Shuo-Qi, Chen, Xiao-Bo, Zheng, Yufeng, and Kannan, M. Bobby (2018) Advances in functionalized polymer coatings on biodegradable magnesium alloys – a review. Acta Biomaterialia, 79. pp. 23-36.

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Abstract

Magnesium (Mg) and its alloys have become a research frontier in biodegradable materials owing to their superior biocompatibility and excellent biomechanical compatibility. However, their high degradation rate in the physiological environment should be well tackled prior to clinical applications. This review summarizes the latest progress in the development of polymeric coatings on biodegradable Mg alloys over the last decade, regarding preparation strategies for polylactic acid (PLA), poly (latic-co-glycolic) acid (PLGA), polycaprolactone (PCL), polydopamine (PDA), chitosan (CS), collagen (Col) and their composite, and their performance in terms of corrosion resistance and biocompatibility. Feasible perspectives and developing directions of next generation of polymeric coatings with respect to biomedical Mg alloys are briefly discussed. Statement of Significance: Magnesium (Mg) and its alloys have become a research frontier in biodegradable materials owing to their superior biocompatibility and suitable biomechanical compatibility. However, the principal drawback of Mg-based implants is their poor corrosion resistance in physiological environments. Hence, it is vital to mitigate the degradation/corrosion behavior of Mg alloys for safe biomedical deployments. This review summarizes the latest progress in development of polymeric coatings on biomedical Mg alloys regarding preparation strategy, corrosion resistance and biocompatibility, including polylactic acid (PLA), poly (latic-co-glycolic) acid (PLGA), polycaprolactone (PCL), chitosan (CS), polydopamine (PDA), collagen (Col) and their composite. In addition, functionalized polymer coatings with Mg alloys exhibits a promising prospect owing to their ability of degradation along with biocompatibility, self-healing, drug-delivery and osteoinduction.

Item ID: 58683
Item Type: Article (Research - C1)
ISSN: 1878-7568
Keywords: Biomaterial; Degradation; Functional properties; Magnesium alloy; Polymer coating
Copyright Information: © 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Funders: National Natural Science Foundation of China (NNSFC), Shandong University of Science and Technology (SDUST)
Projects and Grants: NNSFC grant no:51571134, SDUST grant no:2014TDJH104, SDUST Science and Technology Innovation Fund: SDKDYC180371
Date Deposited: 18 Jun 2019 00:40
FoR Codes: 09 ENGINEERING > 0912 Materials Engineering > 091207 Metals and Alloy Materials @ 100%
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