The evolution and origin of tetrodotoxin acquisition in the blue-ringed octopus (genus Hapalochlaena)

Whitelaw, Brooke L., Cooke, Ira R., Finn, Julian, Zenger, Kyall, and Strugnell, J.M. (2019) The evolution and origin of tetrodotoxin acquisition in the blue-ringed octopus (genus Hapalochlaena). Aquatic Toxicology, 206. pp. 114-122.

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Tetrodotoxin is a potent non-proteinaceous neurotoxin, which is commonly found in the marine environment. Synthesised by bacteria, tetrodotoxin has been isolated from the tissues of several genera including pufferfish, salamanders and octopus. Believed to provide a defensive function, the independent evolution of tetrodotoxin sequestration is poorly understood in most species. Two mechanisms of tetrodotoxin resistance have been identified to date, tetrodotoxin binding proteins in the circulatory system and mutations to voltage gated sodium channels, the binding target of tetrodotoxin with the former potentially succeeding the latter in evolutionary time. This review focuses on the evolution of tetrodotoxin acquisition, in particular how it may have occurred within the blue-ringed octopus genus (Hapalochlaena) and the subsequent impact on venom evolution.

Item ID: 57283
Item Type: Article (Research - C1)
ISSN: 1879-1514
Keywords: tetrodotoxin; octopod; Hapalochlaena; toxin; venom; sodium channel
Copyright Information: © 2018 Elsevier B.V. All rights reserved.
Date Deposited: 04 Mar 2019 02:23
FoR Codes: 31 BIOLOGICAL SCIENCES > 3102 Bioinformatics and computational biology > 310204 Genomics and transcriptomics @ 50%
31 BIOLOGICAL SCIENCES > 3104 Evolutionary biology > 310403 Biological adaptation @ 50%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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