Incident type 2 diabetes in a large Australian cohort study: does physical activity or sitting time alter the risk associated with body mass index?

Nguyen, Binh, Bauman, Adrian, and Ding, Ding (2017) Incident type 2 diabetes in a large Australian cohort study: does physical activity or sitting time alter the risk associated with body mass index? Journal of Physical Activity and Health, 14 (1). pp. 13-19.

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View at Publisher Website: https://doi.org/10.1123/jpah.2016-0184
 
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Abstract

Purpose: To examine the combined effects of body mass index (BMI), physical activity (PA) and sitting on incident type 2 diabetes mellitus (T2DM) among Australian adults.

Methods: A sample of 29,572 adults aged ≥45 years from New South Wales, Australia, completed baseline (2006-2008) and follow-up (2010) questionnaires. Incident T2DM was defined as self-reported, physician-diagnosed diabetes at follow-up. BMI was categorized as normal/overweight/obese. PA was tertiled into low/medium/high. Sitting was dichotomized as higher/lower sitting (≥ 8 hours/day or < 8 hours/day). Odds ratios (OR) were estimated for developing T2DM using logistics regression for individual and combined risk factors, and data stratified by BMI categories.

Results: During a mean 2.7 (SD: 0.9) years of follow-up, 611 (2.1%) participants developed T2DM. In fully adjusted models, BMI was the only independent risk factor for incident T2DM. In stratified analyses, the association between BMI and T2DM did not differ significantly across sitting or PA categories. Overweight/obese individuals with high PA and lower sitting had higher odds of incident T2DM than normal counterparts with low PA and higher sitting.

Conclusions: High PA/low sitting did not attenuate the risk of T2DM associated with overweight/obesity. Maintaining a healthy weight, by adopting healthy lifestyle behaviors, is critical for T2DM prevention.

Item ID: 54088
Item Type: Article (Research - C1)
ISSN: 1543-5474
Keywords: diabetes mellitus; obesity; sedentary behavior
Funders: National Health and Medical Research Council (NHMRC), Cardiovascular Research Network of NSW (CRN), University of Sydney (US)
Projects and Grants: NHMRC Strategic Award for Preventive Healthcare and Strengthening Australia's Social Economic Factor (SEEF project ID 402810), CRN development award, US Merit Award & Women in Science Return to Work Fellowship, NHMRC Early Career Fellowship ref no. 1072223
Date Deposited: 15 Jun 2018 02:20
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1111 Nutrition and Dietetics > 111102 Dietetics and Nutrigenomics @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1111 Nutrition and Dietetics > 111104 Public Nutrition Intervention @ 50%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920408 Health Status (e.g. Indicators of Well-Being) @ 50%
92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920499 Public Health (excl. Specific Population Health) not elsewhere classified @ 50%
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