Effects of dietary intake of garlic on intestinal trematodes

Cortés, Alba, García-Ferrús, Miguel, Sotillo, Javier, Esteban, J. Guillermo, Toledo, Rafael, and Muñoz-Antolí, Carla (2017) Effects of dietary intake of garlic on intestinal trematodes. Parasitology Research, 116 (8). pp. 2119-2129.

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Abstract

The current strategy for the control of helminth infections relies on chemotherapy. However, resistance appearance is promoting the necessity of developing new drugs against trematodes. Herein, potential trematocidal effects of garlic (Allium sativum) are investigated in the context of intestinal foodborne trematodes, employing the Echinostoma caproni-mouse model. Daily administration of dietary doses of garlic was conducted in three groups of mice: (i) before infection (prophylaxis), (ii) after infection (therapeutic) and (iii) both, before and after infection (continuous). A fourth group of mice, not exposed to garlic, was used as control. No differences in worm recovery, fecundity and local cytokine expression profiles were found with respect to control infections. However, considerable alterations in tegument structure, including swelling, furrowing, vacuolization and changes in secretory bodies were detected in garlic-exposed parasites using scanning and transmission electron microscopy. Protein secretion was markedly reduced in response to garlic, whereas up-regulation of several proteins, such as major vault protein and tER-ATPase, was observed in treated worms. The results presented herein provide new insights in the anthelminthic activity of bioactive garlic compounds and the manner that parasites respond to toxins.

Item ID: 53947
Item Type: Article (Research - C1)
ISSN: 1432-1955
Keywords: Allium sativum; anthelmintic activity; Echinostoma caproni: tegument; trematoda
Funders: Ministerio de Economia y Competitividad (MECD), Conselleria d'Educació, Generalitat Valenciana (CE), Red de Investigación Cooperativa en Enfermedades Tropicales (RICET), IV National Program of I+D+I 2008-2011, Subdirección General de Redes y Centros de Investigación Cooperativa (SGRCIC), Ministerio de Sanidad y Consumo (MSC)
Projects and Grants: MECD project BFU2016-75639-P, CE project PROMETEO2014-083 Fase II, RICET No. RD12/0018/0013
Date Deposited: 08 Jun 2018 04:27
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110307 Gastroenterology and Hepatology @ 50%
06 BIOLOGICAL SCIENCES > 0603 Evolutionary Biology > 060307 Host-Parasite Interactions @ 50%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920406 Food Safety @ 50%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920105 Digestive System Disorders @ 50%
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