Brown, S., and Simcock, D.C. (2017) Structural and functional properties of glutamate dehydrogenases. In: D'Mello, J.P.F., (ed.) The Handbook of Microbial Metabolism of Amino Acids. CABI, Oxford, UK, pp. 1-14.

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Abstract

Glutamate dehydrogenases are homooligomeric enzymes that catalyse the reversible oxidative deamination of glutamate to 2-oxoglutarate, thereby linking nitrogen metabolism and the tricarboxylic acid cycle. Four different classes of the enzyme are known in microbes that differ in size and cofactor specificity. Despite some common features, the kinetic properties of the enzymes from different species vary considerably. We consider the relationship between the sequences, those structures that are available and the enzyme kinetics in the context of the metabolic role of the enzyme.

Item ID:	52508
Item Type:	Book Chapter (Research - B1)
ISBN:	978-1-78064-723-4
Keywords:	glutamate dehydrogenase; kinetics; metabolism; structure
Date Deposited:	27 Feb 2018 04:58
FoR Codes:	31 BIOLOGICAL SCIENCES > 3101 Biochemistry and cell biology > 310106 Enzymes @ 50% 31 BIOLOGICAL SCIENCES > 3101 Biochemistry and cell biology > 310103 Cell metabolism @ 40% 31 BIOLOGICAL SCIENCES > 3101 Biochemistry and cell biology > 310112 Structural biology (incl. macromolecular modelling) @ 10%
SEO Codes:	97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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