Myostatin: expanding horizons

Sharma, Mridula, McFarlane, Craig, Kambador, Ravi, Kukreti, Himani, Bonala, Sabeera, and Srinivasan, Shruti (2015) Myostatin: expanding horizons. IUBMB Life, 67 (8). pp. 589-600.

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Abstract

Myostatin is a secreted growth and differentiation factor that belongs to the TGF-b superfamily. Myostatin is predominantly synthesized and expressed in skeletal muscle and thus exerts a huge impact on muscle growth and function. In keeping with its negative role in myogenesis, myostatin expression is tightly regulated at several levels including epigenetic, transcriptional, post-transcriptional, and post-translational. New revelations regarding myostatin regulation also offer mechanisms that could be exploited for developing myostatin antagonists. Increasingly, it is becoming clearer that besides its conventional role in muscle, myostatin plays a critical role in metabolism. Hence, molecular mechanisms by which myostatin regulates several key metabolic processes need to be further explored.

Item ID: 52338
Item Type: Article (Refereed Research - C1)
Keywords: myostatin; skeletal muscle; muscle wasting; cancer cachexia; sarcopenia; insulin resistance
ISSN: 1521-6543
Funders: National Research Foundation (NRF) Singapore, National Medical Research Centre (NMRC)
Date Deposited: 26 Feb 2018 00:13
FoR Codes: 06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060111 Signal Transduction @ 50%
06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060104 Cell Metabolism @ 50%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 50%
97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 40%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920104 Diabetes @ 10%
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