Advances and challenges in barcoding pathogenic and environmental Leptospira

Guernier, Vanina, Allan, Kathryn J., and Goarant, Cyrille (2018) Advances and challenges in barcoding pathogenic and environmental Leptospira. Parasitology, 145 (5). pp. 595-607.

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View at Publisher Website: http://doi.org/10.1017/S0031182017001147
 
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Abstract

Leptospirosis is a zoonotic bacterial disease of global importance. A large spectrum of asymptomatic animal hosts can carry the infection and contribute to the burden of human disease. Environmental sources of human contamination also point to the importance of a hydrotelluric reservoir. Leptospirosis can be caused by as many as 15 different pathogenic or intermediate Leptospira species. However, classification of these bacteria remains complicated through the use of both serological and genetic classification systems that show poor correlation. With the advent of molecular techniques, DNA-based barcoding offers a conceptual framework that can be used for leptospirosis surveillance as well as source tracking. In this review, we summarize some of the current techniques, highlight significant successes and weaknesses and point to the future opportunities and challenges to successfully establish a widely applicable barcoding scheme for Leptospira.

Item ID: 51263
Item Type: Article (Research - C1)
ISSN: 1469-8161
Keywords: leptospirosis; barcoding; molecular epidemiology; epidemiology; genotyping; zoonosis
Funders: Wellcome Trust (WT)
Projects and Grants: WT Veterinary Training Fellowship Grant 096400/Z/11/Z
Date Deposited: 19 Oct 2017 00:04
FoR Codes: 06 BIOLOGICAL SCIENCES > 0604 Genetics > 060408 Genomics @ 40%
06 BIOLOGICAL SCIENCES > 0605 Microbiology > 060501 Bacteriology @ 30%
11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110801 Medical Bacteriology @ 30%
SEO Codes: 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100%
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