Artemisinin-based treatments in pregnant women with mMalaria

Adekunle, Adeshina I., Cromer, Deborah, and Davenport, Miles P. (2016) Artemisinin-based treatments in pregnant women with mMalaria. New England Journal of Medicine, 375 (3). pp. 283-284.

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The Pregnancy Artemisinin-Based Combination Treatments (PREGACT) Study Group compared the polymerase-chain-reaction (PCR)–adjusted “recrudescence” rates of Plasmodium falciparum infection after treatment and suggest that this indicates the failure to eradicate the initial infection (March 10 issue).1 However, analysis of the PCR-adjusted and PCR-unadjusted survival curves of time to “treatment failure” (Fig. S1 in the Supplementary Appendix, available with the full text of the article at suggests that the curves are equally well explained by a constant rate of new infections, a proportion of which are misclassified as recrudescent.

Item ID: 51077
Item Type: Article (Commentary)
ISSN: 1533-4406
Date Deposited: 11 Oct 2017 23:31
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 50%
01 MATHEMATICAL SCIENCES > 0102 Applied Mathematics > 010202 Biological Mathematics @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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