Adekunle, Adeshina I., Cromer, Deborah, and Davenport, Miles P. (2016) Artemisinin-based treatments in pregnant women with mMalaria. New England Journal of Medicine, 375 (3). pp. 283-284.

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Abstract

The Pregnancy Artemisinin-Based Combination Treatments (PREGACT) Study Group compared the polymerase-chain-reaction (PCR)–adjusted “recrudescence” rates of Plasmodium falciparum infection after treatment and suggest that this indicates the failure to eradicate the initial infection (March 10 issue).1 However, analysis of the PCR-adjusted and PCR-unadjusted survival curves of time to “treatment failure” (Fig. S1 in the Supplementary Appendix, available with the full text of the article at NEJM.org) suggests that the curves are equally well explained by a constant rate of new infections, a proportion of which are misclassified as recrudescent.

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