Therapeutic effect of quercetin in collagen-induced arthritis
Haleagrahara, Nagaraja, Miranda-Hernandez, Socorro, Alim, Md Abdul, Hayes, Linda, Bird, Guy, and Ketheesan, Natkunam (2017) Therapeutic effect of quercetin in collagen-induced arthritis. Biomedicine & Pharmacotherapy, 90. pp. 38-46.
|
PDF (Accepted Version)
- Accepted Version
Download (2MB) | Preview |
|
PDF (Published Version)
- Published Version
Restricted to Repository staff only |
Abstract
Quercetin, a bioactive flavonoid with anti-inflammatory, immunosuppressive, and protective properties, is a potential agent for the treatment of rheumatoid arthritis (RA). Collagen-induced arthritis (CIA) is the most commonly used animal model for studying the pathogenesis of RA. This study analysed the therapeutic role of quercetin in collagen-induced arthritis in C57BL/6 mice. The animals were allocated into five groups that were subjected to the following treatments: negative (untreated) control, positive control (arthritis-induced), arthritis + methotrexate, arthritis + quercetin, and arthritis + methotrexate + quercetin. Assessments of weight, oedema, joint damage, and cytokine production were used to determine the therapeutic effect of quercetin. This study demonstrated for the first time the anti-inflammatory and protective effects of quercetin in vivo in CIA. The results also showed that the concurrent administration of quercetin and methotrexate did not offer greater protection than the administration of a single agent. The use of quercetin as a monotherapeutic agent resulted in the lowest degree of joint inflammation and the highest protection. The reduced severity of the disease in animals treated with quercetin was associated with decreased levels of TNF-α, IL-1β, IL-17, and MCP-1. In conclusion, this study determined that quercetin, which was non-toxic, produced better results than methotrexate for the protection of joints from arthritic inflammation in mice. Quercetin may be an alternative treatment for RA because it modulates the main pathogenic pathways of RA.
Item ID: | 48315 |
---|---|
Item Type: | Article (Research - C1) |
ISSN: | 1950-6007 |
Keywords: | collagen-induced arthritis; rheumatoid arthritis; inflammation; quercetin; cytokines; C57BL/6 |
Funders: | Arthritis Australia (AA), Australian Institute of Tropical Health and Medicine (AITHM) |
Projects and Grants: | AA The HJ & GJ McKenzie Grant 2015 |
Date Deposited: | 26 Apr 2017 04:25 |
FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3210 Nutrition and dietetics > 321099 Nutrition and dietetics not elsewhere classified @ 25% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320403 Autoimmunity @ 25% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320223 Rheumatology and arthritis @ 50% |
SEO Codes: | 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920116 Skeletal System and Disorders (incl. Arthritis) @ 75% 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920411 Nutrition @ 25% |
Downloads: |
Total: 1578 Last 12 Months: 20 |
More Statistics |