The therapeutic potential of plant flavonoids on rheumatoid arthritis

Hughes, Samuel D., Ketheesan, Natkunam, and Haleagrahara, Nagaraja (2017) The therapeutic potential of plant flavonoids on rheumatoid arthritis. Critical Reviews in Food Science and Nutrition, 57 (17). pp. 3601-3613.

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Abstract

Rheumatoid arthritis (RA) is an autoimmune condition that mainly affects peripheral joints. Although immunosuppressive drugs and non-steroidal anti-inflammatory drugs (NSAIDs) are used to treat this condition, these drugs have severe side effects. Flavonoids are the most abundant phenolic compounds which exhibit antioxidant, anti-inflammatory and immunomodulatory properties. Many bioactive flavonoids have powerful anti-inflammatory effects. However, a very few have reached clinical use. Dietary flavonoids have been reported to control joint inflammation and alleviate arthritis symptoms in both human RA and animal models of arthritis. There is little scientific evidence about their mechanism of actions in RA. We review the therapeutic effects of different groups of flavonoids belonging to the most common and abundant groups on RA. In particular, the probable mechanisms of major flavonoids on cells and chemical messengers involved in the inflammatory signalling components of RA are discussed in detail.

Item ID: 48003
Item Type: Article (Research - C1)
ISSN: 1549-7852
Keywords: cytokines, inflammation, arthritis, collagen-induced arthritis, immunosuppression
Funders: Arthritis Australia (AA), Australian Institute of Tropical Health and Medicine
Projects and Grants: AA HI and GJ MacKenzie Grant (2015)
Date Deposited: 23 Mar 2017 23:50
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3210 Nutrition and dietetics > 321099 Nutrition and dietetics not elsewhere classified @ 25%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3214 Pharmacology and pharmaceutical sciences > 321402 Clinical pharmacology and therapeutics @ 25%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320223 Rheumatology and arthritis @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 25%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920116 Skeletal System and Disorders (incl. Arthritis) @ 50%
92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920411 Nutrition @ 25%
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