The functional roles of T-cadherin in mammalian biology

Sternberg, Jade, Wankell, Miriam, Subramaniam, V. Nathan, and Hebbard, Lionel (2017) The functional roles of T-cadherin in mammalian biology. AIMS Molecular Science, 4 (1). pp. 62-81.

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T-cadherin is a cadherin and cell adhesion molecule that is anchored to the cell surface membrane through a glycosylphosphatidylinositol moiety. T-cadherin lacks a transmembrane and cytoskeletal domain, suggesting that it must interact with other membrane-bound molecules to elicit cellular signaling to modulate normal cellular functions, and alternatively its absence can be a factor in promoting neoplasia. Moreover, apart from binding to itself it can sequester adiponectin to the cell surface. Consistent with these observations, recent research has expanded the scope of T-cadherin's role in cancer, neuronal function, metabolism and cardiovascular disease. In this context, we highlight the experimental and genomic evidence that links T-cadherin with these diseases. In particular, we discuss how T-cadherin homophilic and heterophilic interactions impact on signaling pathways and cellular behavior.

Item ID: 47664
Item Type: Article (Research - C1)
ISSN: 2372-0301
Additional Information:

© 2017, Lionel W. Hebbard, et al., licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (

Funders: Cancer Council NSW, Queensland Project Grant (QPG), James Cook University, National Health and Medical Research Council of Australia (NHMRC)
Projects and Grants: QPG APP1069733, QPG APP1123426, NHMRC Senior Research Fellowship APP1118888
Date Deposited: 09 Mar 2017 04:07
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321101 Cancer cell biology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%
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