Interleukin-25 induces resistance against intestinal trematodes

Muñoz-Antoli, Carla, Cortes, Alba, Santano, Rebeca, Sotillo, Javier, Esteban, J. Guillermo, and Toledo, Rafael (2016) Interleukin-25 induces resistance against intestinal trematodes. Scientific Reports, 6. 34142. pp. 1-12.

[img]
Preview
PDF (Published Version) - Published Version
Available under License Creative Commons Attribution.

Download (1MB) | Preview
View at Publisher Website: http://dx.doi.org/10.1038/srep34142
 
7
62


Abstract

Echinostoma caproni is an intestinal trematode that has been extensively used as an experimental model to investigate the factors determining the resistance to intestinal helminths or the development of chronic infections. ICR mice are permissive hosts for E. caproni in which chronic infections are developed, concomitantly with local Th1 responses, elevated levels of local IFN-γ, inflammation and antibody responses. However, mice develop partial resistance to homologous challenge infections after cure of a primary infection, which converts this subject into an adequate model for the study of the mechanisms generating resistance against intestinal helminths. The purpose of the present study was to compare the immune response induced in primary and secondary infections to elucidate the factors determining the different outcome of the infection in each type of infection. The results obtained indicate that susceptibility is determined by the lack of IL-25 expression in response to primary infection. In contrast, infection in an environment with elevated levels of IL-25, as occurs in challenge infection, results in a Th2 phenotype impairing parasite survival. This was confirmed by treatment of naïve mice with exogenous IL-25 and subsequent infection. Changes induced in goblet cell populations and mucin glycosylation could be implicated in resistance to infection.

Item ID: 46644
Item Type: Article (Research - C1)
ISSN: 2045-2322
Additional Information:

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2016

Funders: Conselleria d’Educació, Generalitat Valenciana (CEGV) Spain, Ministerio de Economía y Competitividad (MECD), Red de Investigación Cooperativa en Enfermedades Tropicales (RICET), Ministerio de Sanidad y Consumo (MSC)
Projects and Grants: CEGV PROMETEO2014-083 Fase II, MCED BFU2013-41040-P, RICET No. RD12/0018/0013
Date Deposited: 13 Dec 2016 02:07
FoR Codes: 06 BIOLOGICAL SCIENCES > 0603 Evolutionary Biology > 060307 Host-Parasite Interactions @ 20%
11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 10%
06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060109 Proteomics and Intermolecular Interactions (excl Medical Proteomics) @ 70%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 50%
97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 50%
Downloads: Total: 62
Last 12 Months: 30
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page