Bioactive dammarane triterpenoids from the bark of Drypetes acuminata from Paluma, North Queensland, Australia

Pokharel, Suraj K., Setzer, Mary Snow, Greenleaf, Stephanie E., Dosoky, Noura S., Jackes, Betsy R., and Setzer, William N. (2017) Bioactive dammarane triterpenoids from the bark of Drypetes acuminata from Paluma, North Queensland, Australia. Records of Natural Products, 11 (1). pp. 1-8.

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Abstract

Two known triterpenoids, friedelin and aglaitriol, and a new dammarane triterpenoid, aglaitriol 3-caffeate, have been isolated and identified in the chloroform bark extract of Drypetes acuminata P.I. Forst. (Putranjivaceae) from Paluma, north Queensland, Australia. The compounds were screened for antimicrobial and cytotoxic activity. Aglaitriol showed potent cytotoxic activity against three human tumor cell lines (MCF-7, MDA-MB-231, and 5637). Aglaitriol 3-caffeate showed moderate antibacterial activity against Staphylococcus aureus and Escherichia coli. A molecular docking analysis suggests topoisomerase II may be a likely protein target for aglaitriol.

Item ID: 46137
Item Type: Article (Research - C1)
ISSN: 1307-6167
Keywords: Drypetes acuminata; dammarane; aglaitriol; aglaitriol 3-caffeate; cytotoxicity; antibacterial; molecular docking
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Funders: National Institutes of Health (NIH)
Projects and Grants: NIH R15 AIOD39740-01
Date Deposited: 21 Oct 2016 04:18
FoR Codes: 34 CHEMICAL SCIENCES > 3405 Organic chemistry > 340502 Natural products and bioactive compounds @ 95%
31 BIOLOGICAL SCIENCES > 3108 Plant biology > 310802 Plant biochemistry @ 5%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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