Daly, Norelle L., and Rosengren, K. Johan (2015) Structural studies of cyclotides. Advances in Botanical Research, 76. pp. 155-186.

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Abstract

Over the last two decades, the cyclotides have generated widespread interest both in the plant biology and peptide communities for a number of reasons, including their physiological roles in plants, evolution, and wide range of biological activities with potential therapeutic applications. But perhaps most of all it is their unique structure with a cyclic cystine knot motif that provide remarkable features such as resistance to chemical and biological degradation, which have caught researchers' attention. In this chapter, we summarize the key studies that have contributed to our understanding of the cyclotide fold, the structural features of these peptides, and the role and utilization of these features for native and engineered biological function.

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