Age-related cellular changes in the long-lived bivalve A. islandica

Gruber, Heike, Wessels, Wiebke, Boynton, Primrose, Xu, Jinze, Wohlgemuth, Stephanie, Leeuwenburgh, Christiaan, Qi, Wenbo, Austad, Steven N., Schaible, Ralf, and Philipp, Eva E.R. (2015) Age-related cellular changes in the long-lived bivalve A. islandica. Age, 37. pp. 1-12.

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Abstract

One of the biggest challenges to studying causes and effects of aging is identifying changes in cells that are related to senescence instead of simply the passing of chronological time. We investigated two populations of the longest living non-colonial metazoan, Arctica islandica, with lifespans that differed sixfolds. Of four investigated parameters (nucleic acid oxidation, protein oxidation, lipid oxidation, and protein instability), only nucleic acid oxidation increased with age and correlated with relative lifespan. Nucleic acid oxidation levels increased significantly faster and were significantly higher in the shorter-lived than the longer-lived population. In contrast, neither protein oxidation, lipid oxidation, nor protein stability changed over time. Protein resistance to unfolding stress when treated with urea was significantly lower overall in the shorter-lived population, and lipid peroxidation levels were higher in the longer-lived population. With the exception of nucleic acid oxidation, damage levels of A. islandica do not change with age, indicating excellent cellular maintenance in both populations. Since correlations between nucleic acid oxidation and age have also been shown previously in other organisms, and nucleic acid oxidation accumulation rate correlates with relative age in both investigated populations, nucleic acid oxidation may reflect intrinsic aging mechanisms.

Item ID: 44338
Item Type: Article (Research - C1)
ISSN: 1574-4647
Keywords: longevity; aging marker; Arctica islandica; oxidation; cellular maintenance
Funders: Institute of Clinic Molecular Biology, Germany, Excellence Clusters Future Ocean and Inflammation of Interfaces, Max Planck International Research Network on Aging
Date Deposited: 16 Jun 2016 23:53
FoR Codes: 06 BIOLOGICAL SCIENCES > 0606 Physiology > 060603 Animal Physiology Systems @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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