Low disease-causing threshold in a frog species susceptible to chytridiomycosis

Stockwell, Michelle P., Garnham, James I., Clulow, John, Bower, Deborah S., and Mahony, Michael J. (2016) Low disease-causing threshold in a frog species susceptible to chytridiomycosis. FEMS Microbiology Letters, 363 (12). fnw111. pp. 1-6.

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View at Publisher Website: http://dx.doi.org/10.1093/femsle/fnw111
 
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Abstract

A simple diagnosis of the presence or absence of an infection is an uninformative metric when individuals differ considerably in their tolerance to different infection loads or resistance to rates of disease progression. Models that incorporate the relationship between the progression of the infection with the potential alternate outcomes provide a far more powerful predictive tool than diagnosis alone. The global decline of amphibians has been amplified by Batrachochytrium dendrobatidis, a pathogen that can cause the fatal disease chytridiomycosis. We measured the infection load and observed signs of disease in Litoria aurea. Receiver operating characteristic curves were used to quantify the dissimilarity between the infection loads of L. aurea that showed signs associated with chytridiomycosis and those that did not. Litoria aurea had a 78% probability of developing chytridiomycosis past a threshold of 68 zoospore equivalents (ZE) per swab and chytridiomycosis occurred within a variable range of 0.5–490 ZE. Studies should incorporate a species-specific threshold as a predictor of chytridiomycosis, rather than a binary diagnosis. Measures of susceptibility to chytridiomycosis must account not only for the ability of B. dendrobatidis to increase its abundance on the skin of amphibians but also to determine how each species tolerates these infection loads.

Item ID: 43964
Item Type: Article (Research - C1)
ISSN: 1574-6968
Keywords: Litoria aurea, receiver operating characteristic, Batrachochytrium dendrobatidis, radio-tracking, susceptibility
Funders: Port Waratah Coal Service (PWCS), Kooragang Wetland Rehabilitation Project (KWRP), Australian Research Council (ARC)
Projects and Grants: ARC Linkage Grant LP0989459
Date Deposited: 26 Jul 2016 01:06
FoR Codes: 05 ENVIRONMENTAL SCIENCES > 0502 Environmental Science and Management > 050206 Environmental Monitoring @ 50%
06 BIOLOGICAL SCIENCES > 0602 Ecology > 060299 Ecology not elsewhere classified @ 50%
SEO Codes: 96 ENVIRONMENT > 9608 Flora, Fauna and Biodiversity > 960899 Flora, Fauna and Biodiversity of Environments not elsewhere classified @ 100%
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