Daly, Norelle, Wilson, David, and Craik, David (2012) Cyclic peptides from plants and their promise in drug design. Australian Biochemist, 43 (2). pp. 7-9.

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Abstract

[Extract] Gene-encoded cyclic peptides were originally thought to be anomalies in the peptide world, but are now known to be widespread throughout nature, with examples in plants, bacteria, fungi, and mammals. Recent studies have provided fascinating insights into how these cyclic peptides are made and have highlighted their potential in pharmaceutical and agricultural applications. It is becoming apparent that this relatively new fi of gene- encoded cyclic peptides is quite diverse, particularly in terms of the structures present and the biosynthetic processes. The structures range from large peptides (~70 residues) containing primarily α-helical structures to small β-hairpins (12-14 residues), as shown in Fig. l. The biosynthesis is only beginning to be understood, but it is clear that protease-mediated mechanisms are involved in the formation of cyclic peptides.

Item ID:	39219
Item Type:	Article (Non-Refereed Research)
ISSN:	1443-0193
Date Deposited:	29 Oct 2015 00:27
FoR Codes:	03 CHEMICAL SCIENCES > 0304 Medicinal and Biomolecular Chemistry > 030406 Proteins and Peptides @ 100%
SEO Codes:	97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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