Were arachnids the first to use combinatorial peptide libraries?

Sollod, Brianna L., Wilson, David, Zhaxybayeva, Olga, Gogarten, J. Peter, Drinkwater, Roger, and King, Glenn F. (2005) Were arachnids the first to use combinatorial peptide libraries? Peptides, 26 (1). pp. 131-139.

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Spiders, scorpions, and cone snails are remarkable for the extent and diversity of gene-encoded peptide neurotoxins that are expressed in their venom glands. These toxins are produced in the form of structurally constrained combinatorial peptide libraries in which there is hypermutation of essentially all residues in the mature-toxin sequence with the exception of a handful of strictly conserved cysteines that direct the three-dimensional fold of the toxin. This gene-based combinatorial peptide library strategy appears to have been first implemented by arachnids almost 400 million years ago, long before cone snails evolved a similar mechanism for generating peptide diversity.

Item ID: 39021
Item Type: Article (Research - C1)
ISSN: 1873-5169
Keywords: peptide toxin; toxin evolution; combinatorial peptide library; spider; scorpion; arachnid; cone snail; atracotoxin; conotoxin; prepropeptide; toxin precursor; cysteine scaffold
Funders: National Science Foundation (NSF), National Institute of Allergy and Infectious Diseases (NIAID)
Projects and Grants: NSF MCB9983242, NSF MCB0237197, NIAID 1-R41-AI51791
Date Deposited: 25 Jun 2015 03:48
FoR Codes: 03 CHEMICAL SCIENCES > 0304 Medicinal and Biomolecular Chemistry > 030406 Proteins and Peptides @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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