Insights into Acinetobacter baumannii pathogenicity

Cerqueira, Gustavo M., and Peleg, Anton Y. (2011) Insights into Acinetobacter baumannii pathogenicity. IUBMB Life, 63 (12). pp. 1055-1060.

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Acinetobacter spp. have justifiably received significant attention from the public, scientific, and medical communities. Over recent years, Acinetobacter, particularly Acinetobacter baumannii, has become a "red-alert" human pathogen, primarily because of its exceptional ability to develop resistance to all currently available antibiotics. This characteristic is compounded by its unique abilities to survive in a diverse range of environments, including those within healthcare institutions, leading to problematic outbreaks. Historically, the virulence of the organism has been questioned, but recent clinical reports suggest that Acinetobacter can cause serious, life-threatening infections. Furthermore, its metabolic adaptability gives it a selective advantage in harsh hospital environments. This review focuses on current understanding of A. baumannii pathogenesis and the model systems used to study this interesting organism.

Item ID: 37412
Item Type: Article (Research - C1)
ISSN: 1521-6551
Keywords: A. baumannii; antibiotic resistance; nosocomial infection; pathogenesis; virulence
Funders: National Health and Medical Research Council of Australia (NHMRC)
Projects and Grants: NHMRC project grant APP1010114
Date Deposited: 12 Mar 2015 03:46
FoR Codes: 06 BIOLOGICAL SCIENCES > 0605 Microbiology > 060502 Infectious Agents @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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