The glyoxylate cycle in Ostertagia (Teladorsagia) circumcincta

Simcock, D.C., Walker, L.R., Pedley, K.C., Simpson, H.V., and Brown, S. (2007) The glyoxylate cycle in Ostertagia (Teladorsagia) circumcincta. New Zealand Journal of Zoology, 34 (2). pp. 153-154.

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Abstract

Ostertagia (Teladorsagia) circumcincta is a nematode parasite which infects the abomasum of sheep and goats. The utilisation of substrates for energy production in O. circumcincta is largely unknown. This parasite has been shown to consume oxygen, and have a full glycolytic and TCA cycle in both L3 and adult stages, although the metabolism of carbohydrates in adults appears to be more geared towards an anaerobic pathway. As well as glycogen, O. circumcincta also contains high levels of stored lipid in both L3 and adult stages, which could also be utilised to provide energy. However, the relative importance of glycogen and lipid for energy production is unknown: in the L3, in which nutrient intake is thought to be restricted by the presence of the sheath; or the adult, in which lipid metabolism may be restricted by oxygen supply. The key enzymes of the glyoxylate cycle, malate synthase and isocitrate would allow this parasite to convert lipid to glucose for metabolism via glycolysis. The enzyme phosphoenolpyruvate carboxykinase (PEPCK) has also been detected in both L3 and adult O. circumcincta. Although this enzyme is typically associated with anaerobic metabolism in nematode parasites, it is also central to gluconeogenesis. As the O. circumcincta has a full TCA cycle and consumes oxygen, gluconeogenesis may be the key function of PEPCK in this parasite species, particularly in L3s. The activity of the glyoxylate cycle along relative levels of glycogen and lipid in L3 and adults of different ages will be discussed.

Item ID: 36391
Item Type: Article (Abstract)
ISSN: 1175-8821
Additional Information:

Abstract from the 33rd conference of the New Zealand society for Parasitology, at Massey University, Palmerston North, 24 October 2006

Date Deposited: 25 Sep 2015 01:48
FoR Codes: 06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060104 Cell Metabolism @ 40%
06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060107 Enzymes @ 30%
06 BIOLOGICAL SCIENCES > 0606 Physiology > 060604 Comparative Physiology @ 30%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 50%
97 EXPANDING KNOWLEDGE > 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences @ 50%
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