Gastrin secretion by ovine antral mucosa in vitro

Lawton, D.E.B., Simcock, D.C., Candy, E.J., and Simpson, H.V. (2000) Gastrin secretion by ovine antral mucosa in vitro. Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology, 126 (2). pp. 233-243.

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The effect on gastrin and somatostatin release in sheep of stimulatory and inhibitory peptides and pharmacological agents was investigated using an in vitro preparation of ovine antral mucosa. Carbachol stimulated gastrin release in a dose-dependent manner but had no effect on somatostatin release. As atropine blocked the effect of carbachol, cholinergic agonists appear to stimulate gastrin secretion directly through muscarinic receptors on the G-cell and not by inhibition of somatostatin secretion. Both vasoactive-intestinal peptide (VIP) and gastric-inhibitory peptide (GIP) increased somatostatin release but did not inhibit basal gastrin secretion, although VIP was effective in reducing the gastrin response to Gastrin-releasing peptide (GRP). Porcine and human GRP were stimulatory to gastrin secretion in high doses but bombesin was without effect. The relative insensitivity to GRP (not of ovine origin) previously reported from intact sheep may be caused either by a high basal release of somatostatin or by the ovine GRP receptor or peptide differing from those of other mammalian species.

Item ID: 36385
Item Type: Article (Research - C1)
ISSN: 1531-4332
Keywords: carbachol; gastrin; GIP; GRP; in vitro; somatostatin; sheep; VIP
Funders: C. Alma Baker Trust, E. & C. Thoms Bequest, Massey University
Date Deposited: 24 Sep 2015 23:36
FoR Codes: 06 BIOLOGICAL SCIENCES > 0606 Physiology > 060604 Comparative Physiology @ 50%
06 BIOLOGICAL SCIENCES > 0606 Physiology > 060602 Animal Physiology - Cell @ 50%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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