Abomasal bacteria produce an inhibitor of gastrin secretion in vitro

Simcock, D.C., Lawton, D.E.B., Scott, I., and Simpson, H.V. (2006) Abomasal bacteria produce an inhibitor of gastrin secretion in vitro. Research in Veterinary Science, 81 (1). pp. 152-157.

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Previously, proliferating microflora transferred with abomasal nematodes, were suspected to be the source of the gastrin inhibitor in some parasite excretory/secretory products. Aerobic cultures in HBSS of abomasal fluid from uninfected sheep became inhibitory during the static growth phase, unless antibiotics were present. Basal gastrin secretion was reduced by up to 90%. Rumen fluid and incubates and medium in which Streptococcus bovis and ovine rumen Actinomycete spp. had been grown also contained the inhibitor. Unlike abomasal cultures, rumen fluid and incubates also reduced the measurement of gastrin standards. Rumen incubates were less potent after exposure to pH 2–3, suggesting that inactivation normally occurs in the unparasitised abomasum. Contaminating bacteria which generate the gastrin inhibitor in parasite ES products are probably rumen organisms which survive in the abomasum and proliferate during subsequent incubation. Significantly, rumen bacteria have been shown to be capable of affecting the secretory activity of the gastric mucosa.

Item ID: 36375
Item Type: Article (Research - C1)
ISSN: 1532-2661
Keywords: abomasal parasites; ES products; gastrin inhibitor; abomasal bacteria; rumen microflora
Funders: C. Alma Baker Trust, E. & C. Thoms Bequest, Massey University
Date Deposited: 25 Sep 2015 01:02
FoR Codes: 06 BIOLOGICAL SCIENCES > 0606 Physiology > 060602 Animal Physiology - Cell @ 50%
06 BIOLOGICAL SCIENCES > 0606 Physiology > 060699 Physiology not elsewhere classified @ 50%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 50%
97 EXPANDING KNOWLEDGE > 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences @ 50%
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