Abomasal contents of parasitised sheep contain an inhibitor of gastrin secretion in vitro

Simcock, D.C., Scott, I., Przemeck, S.M.C, and Simpson, H.V. (2006) Abomasal contents of parasitised sheep contain an inhibitor of gastrin secretion in vitro. Research in Veterinary Science, 81 (2). pp. 225-230.

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Serum gastrin concentrations are typically elevated in parasitised sheep; however, in some animals serum gastrin concentrations may fall abruptly despite a very high abomasal pH. Although proliferating abomasal bacteria in culture generate a potent inhibitor of in vitro gastrin secretion, this inhibitor has not been detected in abomasal contents of unparasitised sheep. In sheep parasitised by O. circumcincta, all abomasal fluid samples of pH 5 and above were inhibitory to gastrin release in vitro. Inhibitory activity and abomasal pH were correlated in two separate experiments; the model best fitting the data being sigmoidal in each case, with zero activity at pH 3.6 and 4.6, respectively. There was no clear evidence that the presence of a gastrin inhibitor in the abomasal contents reduced the serum gastrin concentration in parasitised sheep. Serum gastrin was correlated with abomasal pH (log10 serum gastrin concentrations conformed to log-linear sigmoidal models).

Item ID: 36374
Item Type: Article (Research - C1)
ISSN: 1532-2661
Keywords: Ostertagia (Teladorsagia) circumcincta; gastrin; abomasal bacteria; abomasal pH
Funders: C. Alma Baker Trust, E. & C. Thoms Bequest, Massey University
Date Deposited: 25 Sep 2015 01:08
FoR Codes: 06 BIOLOGICAL SCIENCES > 0606 Physiology > 060602 Animal Physiology - Cell @ 50%
07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070708 Veterinary Parasitology @ 50%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 50%
97 EXPANDING KNOWLEDGE > 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences @ 50%
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