Nitrogen excretion by the sheep abomasal parasite Teladorsagia circumcincta

Simpson, H.V., Muhamad, N., Walker, L.R., Simcock, D.C., Brown, S., and Pedley, K.C. (2009) Nitrogen excretion by the sheep abomasal parasite Teladorsagia circumcincta. Experimental Parasitology, 123 (1). pp. 17-23.

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Excretion of nitrogenous substances by Teladorsagia circumcincta was investigated during incubation of L3 in phosphate buffer for up to 30 h and adult worms for 4–6 h. Ammonia was the main excretory product, with about 20% urea. For the first 4–6 h, ammonia excretion by L3 was temperature dependent, directly proportional to the number of larvae, but independent of the pH or strength of the phosphate buffer. Later, ammonia excretion slowed markedly in L3 and adults and reversed to net uptake in L3 by 30 h. An initial external ammonia concentration of 600 μM did not alter the pattern or magnitude of excretion. Re-uptake of ammonia did not occur at extremes of pH or low buffer strength and was slightly reduced at the highest external concentrations. Ammonium transporters and enzymes of glutamate metabolism, including glutamate dehydrogenase, glutamine synthetase and possibly glutamate synthase, are worthy of further investigation as anthelmintic targets.

Item ID: 35758
Item Type: Article (Research - C1)
ISSN: 1090-2449
Keywords: nematode, Teladorsagia (Ostertagia) circumcincta, nitrogen excretion, ammonia
Funders: Meat and Wool New Zealand, E. and C. Thoms Bequest
Date Deposited: 15 Oct 2014 16:48
FoR Codes: 06 BIOLOGICAL SCIENCES > 0606 Physiology > 060604 Comparative Physiology @ 50%
07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070708 Veterinary Parasitology @ 50%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 50%
97 EXPANDING KNOWLEDGE > 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences @ 50%
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