Imidazole initiates exsheathing of L3 Teladorsagia circumcincta

Brown, Simon, Neale, Jennifer D., Nava-Tirado, Magnolia, Simpson, Heather V., Pedley, Kevin C., and Simcock, David C. (2013) Imidazole initiates exsheathing of L3 Teladorsagia circumcincta. Journal of Parasitology, 99 (2). pp. 332-336.

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The infective larvae of Teladorsagia circumcincta have a protective sheath that is lost soon after they reach the rumen of the sheep (the definitive host). Incubation in vitro with 50 mM imidazole caused more than 75% of L3 T. circumcincta to begin exsheathing within 2 hr. The initiation of exsheathing was less likely at pH 6.2 than at pH 7.8. The apparent pKa of this process was 7.08, similar to that for the conversion of imidazolium+ to imidazole. Both the extent and the initial rate of exsheathing initiation increased with imidazole concentration (the apparent K½ was about 50 mM). The initial rate of exsheathing initiation was stimulated by lactose and maltose, but not by some other carbohydrates, and by propylamine and imidazole acetic acid, but not by histidine.

Item ID: 35750
Item Type: Article (Research - C1)
ISSN: 1937-2345
Funders: Beef and Lamb New Zealand, Agricultural and Marketing Research and Development Trust (AGMARDT)
Date Deposited: 15 Oct 2014 16:48
FoR Codes: 06 BIOLOGICAL SCIENCES > 0606 Physiology > 060604 Comparative Physiology @ 50%
07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070708 Veterinary Parasitology @ 50%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 50%
97 EXPANDING KNOWLEDGE > 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences @ 50%
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