A golden bullet? Selective targeting of Toxoplasma gondii tachyzoites using antibody-functionalized gold nanorods

Pissuwan, Dakrong, Valenzuela, Stella M., Miller, Catherine M., and Cortie, Michael (2007) A golden bullet? Selective targeting of Toxoplasma gondii tachyzoites using antibody-functionalized gold nanorods. Nano Letters, 7 (12). pp. 3808-3812.

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Abstract

Conjugates of gold nanoparticles and antibodies have useful functionalities. Here, we show how they can be used to selectively target and destroy parasitic protozoans. Gold nanorods were conjugated with an anti-Toxoplasma gondii antibody and used to target the extracellular tachyzoite which is an infectious form of an obligate parasite Toxoplasma gondii. Subsequent laser irradiation was used to kill the targeted protozoans. This concept provides a new paradigm for the treatment of parasitic protozoans.

Item ID: 34597
Item Type: Article (Refereed Research - C1)
Keywords: Toxoplasma gondii; nanorods; antibodies
ISSN: 1530-6992
Date Deposited: 26 Aug 2014 03:52
FoR Codes: 10 TECHNOLOGY > 1007 Nanotechnology > 100703 Nanobiotechnology @ 70%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110702 Applied Immunology (incl Antibody Engineering, Xenotransplantation and T-cell Therapies) @ 30%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970110 Expanding Knowledge in Technology @ 50%
97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 50%
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