Ontogeny of immunoglobulin expression in the brushtail possum (Trichosurus vulpecula)

Belov, Katherine, Nguyen, Mai-Anh T., Zenger, Kyall R., and Cooper, Desmond W. (2002) Ontogeny of immunoglobulin expression in the brushtail possum (Trichosurus vulpecula). Developmental and Comparative Immunology, 26 (7). pp. 599-602.

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Marsupials, unlike eutherians, are born immunologically immature, without circulating lymphocytes or organised lymphoid tissue. Their immune response develops while they are in the pouch not in the uterus. In this study, the onset time of immunoglobulin expression in Trichosurus vulpecula pouch young was estimated by reverse transcription polymerase chain reaction. As in eutherian species, IgM heavy chain transcripts were detected first, at day 10 post partum. The first switched transcript, detected at day 18, was Calpha. Cgamma and Cvarepsilon transcripts were not present at day 72, but were seen at day 103, approximately corresponding to the time of release of the teat and exposure to new antigens, as well as the time of the loss of capacity to absorb maternal Igs through the gut.

Item ID: 34219
Item Type: Article (Research - C1)
ISSN: 1879-0089
Keywords: Trichosurus vulpecula; marsupial; pouch young; heavy chain; immunoglobulin; ontogeny
Funders: New Zealand Ministry of Agriculture and Forestry
Date Deposited: 14 Aug 2014 04:14
FoR Codes: 06 BIOLOGICAL SCIENCES > 0603 Evolutionary Biology > 060305 Evolution of Developmental Systems @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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