Polymer encapsulation of magnesium to control biodegradability and biocompatibility

Bazaka, Kateryna, Ketheesan, Natkunam, and Jacob, Mohan V. (2014) Polymer encapsulation of magnesium to control biodegradability and biocompatibility. Journal of Nanoscience and Nanotechnology, 14 (10). pp. 8087-8093.

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Clinical utility of biodegradable magnesium implants is undermined by the untimely degradation of these materials in vivo. Their high corrosion rate leads to loss of mechanical integrity, peri–implant alkalization and localised accumulation of hydrogen gas. Biodegradable coatings were produced on pure magnesium using RF plasma polymerisation. A monoterpene alcohol with known anti-inflammatory and antibacterial properties was used as a polymer precursor. The addition of the polymeric layer was found to reduce the degradation rate of magnesium in simulated body fluid. The in vitro studies indicated good cytocompatibility of non-adherent THP–1 cells and mouse macrophage cells with the polymer, and the polymer coated sample. The viability of THP–1 cells was significantly improved when in contact with polymer encapsulated magnesium compared to unmodified samples. Collectively, these results suggest plasma enhanced polymer encapsulation of magnesium as a suitable method to control degradation kinetics of this biomaterial.

Item ID: 34120
Item Type: Article (Research - C1)
ISSN: 1533-4899
Keywords: magnesium, implantable materials, biocompatibility, encapsulation
Funders: James Cook University (JCU), Australian Research Council (ARC)
Projects and Grants: JCU Collaboration Across Boundaries grant, ARC DECRA DE130101550
Date Deposited: 16 Jul 2014 09:19
FoR Codes: 09 ENGINEERING > 0912 Materials Engineering > 091209 Polymers and Plastics @ 50%
09 ENGINEERING > 0912 Materials Engineering > 091207 Metals and Alloy Materials @ 50%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970109 Expanding Knowledge in Engineering @ 100%
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