ANKH polymorphisms and clicking of the temporomandibular joint in dental residents

Huang, Boyen, Takahashi, Katsu, Goto, Tomoko, Kiso, Honoka, Sugai, Manabu, Shimizu, Akira, Kosugi, Shinji, and Bessho, Kazuhisa (2015) ANKH polymorphisms and clicking of the temporomandibular joint in dental residents. Journal of Maxillofacial and Oral Surgery, 14 (2). pp. 247-251.

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Abstract

Aim

This study aimed to carry out a case-control research study to assess occurrence of clicking of the temporomandibular joint (TMJ) in order to establish the relationship between TMJ clicking and the genotype of "ANKH inorganic pyrophosphate transport regulator" (ANKH) polymorphisms.

Materials and Method

A sample of 41 first-year dental residents was selected. Each was examined using standard clinical procedures and genotyping techniques.

Results

The participation rate was 91.8 %. The prevalence of TMJ clicking was 51.2 % (95 % CI: 35.7–66.7 %). Occurrence of TMJ clicking was not related to age, gender and genotypes of ANKH-OR as well as ANKH-TR polymorphisms (p ≥ 0.165).

Conclusion

A similar distribution of ANKH genotypes in TMJ clicking and asymptomatic individuals has been demonstrated by this study. A high percentage of TMJ clicking has been confirmed. Future investigations are indicated.

Item ID: 33511
Item Type: Article (Refereed Research - C1)
Keywords: Temporomandibular disorders, clicking, ANKH, polymorphism, oral surgeon
ISSN: 0974-942X
Funders: Japanese Society for the Promotion of Science (JSPS)
Projects and Grants: JSPS Grant-in-Aid for Scientific Research (B)
Date Deposited: 04 Jun 2014 01:19
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1105 Dentistry > 110504 Oral and Maxillofacial Surgery @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1105 Dentistry > 110505 Oral Medicine and Pathology @ 10%
06 BIOLOGICAL SCIENCES > 0604 Genetics > 060499 Genetics not elsewhere classified @ 40%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920113 Oro-Dental Disorders @ 80%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920116 Skeletal System and Disorders (incl. Arthritis) @ 20%
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