Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines

Bertucci, Anthony, Zoccola, Didier, Tambutté, Sylvie, Vullo, Daniella, and Supuran, Claudiu T. (2010) Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines. Bioorganic & Medicinal Chemistry, 18. pp. 2300-2303.

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Abstract

The activity of the coral Stylophora pystillata secretory carbonic anhydrase STPCA has been tested in presence of amino acids and amines. All the investigated compounds showed a positive, activating effect on kcat and have been separated in weak (KA in the range of 21–126 μM), medium (10.1–19 μM) and strong enzyme activators (KA of 0.18–3.21 μM). D-DOPA was found to be the best coral enzyme activator, with an activation constant KA of 0.18 μM. This enhancement of STPCA activity, as well as previous enzyme inhibition results, might now be tested on living organisms to better understand the role played by these enzymes in the coral calcification processes.

Item ID: 31635
Item Type: Article (Research - C1)
ISSN: 1464-3391
Funders: European Union Sixth Framework Program (EU FP6), Fondo per Gli Investimenti Della Ricerca di Base (FIRB), Centre Scientifique de Monaco
Date Deposited: 24 Sep 2014 05:25
FoR Codes: 06 BIOLOGICAL SCIENCES > 0606 Physiology > 060604 Comparative Physiology @ 50%
06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060107 Enzymes @ 50%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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