Genome of the human hookworm Necator americanus

Tang, Yat T., Gao, Xin, Rosa, Bruce A., Abubucker, Sahar, Hallsworth-Pepin, Kymberlie, Martin, John, Tyagi, Rahul, Heizer, Esley, Zhang, Xu, Bhonagiri-Palsikar, Veena, Minx, Patrick, Warren, Wesley C., Wang, Qi, Zhan, Bin, Hotez, Peter J., Sternberg, Paul W., Dougall, Annette, Gaze, Soraya Torres, Mulvenna, Jason, Sotillo, Javier, Ranganathan, Shoba, Rabelo, Elida M., Wilson, Richard K., Felgner, Philip L., Bethony, Jeffrey, Hawdon, John M., Gasser, Robin B., Loukas, Alex, and Mitreva, Makedonka (2014) Genome of the human hookworm Necator americanus. Nature Genetics, 46 (3). pp. 261-271.

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Abstract

The hookworm Necator americanus is the predominant soil-transmitted human parasite. Adult worms feed on blood in the small intestine, causing iron-deficiency anemia, malnutrition, growth and development stunting in children, and severe morbidity and mortality during pregnancy in women. We report sequencing and assembly of the N. americanus genome (244 Mb, 1 19,151 1 genes). Characterization of this first hookworm genome sequence identified genes orchestrating the hookworm's invasion of the human host, genes involved in blood feeding and development, and genes encoding proteins that represent new potential drug targets against hookworms. N. americanus has undergone a considerable and unique expansion of immunomodulator proteins, some of which we highlight as potential treatments against inflammatory diseases. We also used a protein microarray to demonstrate a postgenomic application of the hookworm genome sequence. This genome provides an invaluable resource to boost ongoing efforts toward fundamental and applied postgenomic research, including the development of new methods to control hookworm and human immunological diseases.

Item ID: 31353
Item Type: Article (Research - C1)
ISSN: 1546-1718
Additional Information:

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.

Funders: US National Institutes of Health (NIH), Australian Research Council (ARC), National Health and Medical Research Council (NHMRC)
Projects and Grants: NIH-National Human Genome Research Institute grant U54HG003079, NIH-National Institute of Allergy and Infectious Diseases AI081803, NIH-National Institute of General Medical Sciences GM097435
Date Deposited: 25 Feb 2014 23:35
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 35%
06 BIOLOGICAL SCIENCES > 0603 Evolutionary Biology > 060307 Host-Parasite Interactions @ 35%
06 BIOLOGICAL SCIENCES > 0604 Genetics > 060406 Genetic Immunology @ 30%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 60%
97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 20%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 20%
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