Different bacterial pathogens, different strategies, yet the aim is the same: evasion of intestinal dendritic cell recognition

Bedoui, Sammy, Kupz, Andreas, Wijburg, Odilia L., Walduck, Anna K., Rescigno, Maria, and Strugnell, Richard A. (2010) Different bacterial pathogens, different strategies, yet the aim is the same: evasion of intestinal dendritic cell recognition. Journal of Immunology, 184 (5). pp. 2237-2242.

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Abstract

Given the central role of intestinal dendritic cells (DCs) in the regulation of gut immune responses, it is not surprising that several bacterial pathogens have evolved strategies to prevent or bypass recognition by DCs. In this article, we will review recent findings on the interaction between intestinal DCs and prototypical bacterial pathogens, such as Salmonella, Yersinia, or Helicobacter. We will discuss the different approaches with which these pathogens seek to evade DC recognition and subsequent T cell activation. These diverse strategies span to include mounting irrelevant immune responses, inhibition of Ag presentation by DCs, and stretch as far as to manipulate the Th1/Th2 balance of CD4+ T cells in the bacteria's favor.

Item ID: 30938
Item Type: Article (Research - C1)
ISSN: 1550-6606
Date Deposited: 04 Jul 2014 06:38
FoR Codes: 06 BIOLOGICAL SCIENCES > 0605 Microbiology > 060502 Infectious Agents @ 40%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110707 Innate Immunity @ 30%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110701 Allergy @ 30%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 65%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 35%
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