Fabrication of matrix-structured microspheres through break-up of a flow-focused laminar water-in-oil emulsion jet

Yinghe, He (2007) Fabrication of matrix-structured microspheres through break-up of a flow-focused laminar water-in-oil emulsion jet. In: Proceedings of the 35th Australasian Chemical Enginering Conferrence 2007. pp. 382-388. From: CHEMECA 2007: academia and industry - strengthening the profession, 23-26 September 2007, Melbourne, Victoria, Australia.

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Many applications such as controlled drug release, food flavouring and cosmetic colouring require the packaging of different ingredients into a particulate form to achieve desired end-use performances. However, control or even prediction of powder performances is a well known difficult task. The difficulties are essentially caused by the heterogeneous nature of the particle assembly reflected in the broad distribution of their sizes, shapes and structures. To achieve a better predicability and ultimate control of particle performances, many research efforts have recently been directed towards the production of particles with controlled attributes, i.e. structured particles with a very narrow size distribution, or structured monodisperse "designer" particles. This paper presents an innovative technology for the production of monodisperse designer microspheres. The technology uses a monodisperse water-in-oil-in-water dispersion as templates, generated through the break-up of a flow-focused laminar water-in-oil emulsion jet. The templates are then converted into solid microspheres with a matrix structure by solvent evaporation. The technology is capable of producing monodisperse microspheres in the size range of 20 to 200 microns with near 100% encapsulation efficiencies. It is particularly suitable for the production of particulate systems for the delivery of water-soluble drug compounds.

Item ID: 3081
Item Type: Conference Item (Research - E1)
ISBN: 0-85825-844-7
Keywords: emulsion jet; flow focusing; particle design; laminar jet break-up; microencapsulation; matrix-structured particles
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Date Deposited: 29 Sep 2009 04:53
FoR Codes: 09 ENGINEERING > 0904 Chemical Engineering > 090499 Chemical Engineering not elsewhere classified @ 40%
11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified @ 30%
07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070799 Veterinary Sciences not elsewhere classified @ 30%
SEO Codes: 86 MANUFACTURING > 8608 Human Pharmaceutical Products > 860801 Human Biological Preventatives (e.g. Vaccines) @ 51%
86 MANUFACTURING > 8609 Veterinary Pharmaceutical Products > 860901 Veterinary Biological Preventatives (e.g. Vaccines) @ 49%
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