Phyletic distribution of fatty acid-binding protein genes

Zheng, Yadong, Blair, David, and Bradley, Janette E. (2013) Phyletic distribution of fatty acid-binding protein genes. PLoS ONE, 8 (10). e77636. pp. 1-9.

[img]
Preview
PDF (Published Version) - Published Version
Available under License Creative Commons Attribution.

Download (781kB)
View at Publisher Website: http://dx.doi.org/10.1371/journal.pone.0...
 
10
72


Abstract

Fatty acid-binding proteins (FABPs) are a family of fatty acid-binding small proteins essential for lipid trafficking, energy storage and gene regulation. Although they have 20 to 70% amino acid sequence identity, these proteins share a conserved tertiary structure comprised of ten beta sheets and two alpha helixes. Availability of the complete genomes of 34 invertebrates, together with transcriptomes and ESTs, allowed us to systematically investigate the gene structure and alternative splicing of FABP genes over a wide range of phyla. Only in genomes of two cnidarian species could FABP genes not be identified. The genomic loci for FABP genes were diverse and their genomic structure varied. In particular, the intronless FABP genes, in most of which the key residues involved in fatty acid binding varied, were common in five phyla. Interestingly, several species including one trematode, one nematode and four arthropods generated FABP mRNA variants via alternative splicing. These results demonstrate that both gene duplication and post-transcriptional modifications are used to generate diverse FABPs in species studied.

Item ID: 30402
Item Type: Article (Research - C1)
ISSN: 1932-6203
Additional Information:

© 2013 Zheng et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Funders: Overseas Research Students Awards (ORS), University of Nottingham Scholarship (UK), Lanzhou Veterinary Research Institute, China
Date Deposited: 27 Nov 2013 05:31
FoR Codes: 06 BIOLOGICAL SCIENCES > 0603 Evolutionary Biology > 060309 Phylogeny and Comparative Analysis @ 100%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920405 Environmental Health @ 100%
Downloads: Total: 72
Last 12 Months: 18
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page