Approaches to diagnosing Anisakis allergy: allergies in the workplace ALLSA research awards report

Nieuwenhuizen, Natalie, Jeebhay, Mohamed, and Lopata, Andreas L. (2009) Approaches to diagnosing Anisakis allergy: allergies in the workplace ALLSA research awards report. Current Allergy and Clinical Immunology, 22 (3). pp. 132-138.

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Anisakis is a parasitic nematode which infects fish and can cause gastrointestinal disease if accidentally ingested. Infection can be accompanied by severe allergic reactions such as urticaria, angio-oedema and anaphylaxis. Furthermore, workers involved in fish processing can develop occupational allergy to Anisakis, including asthma, rhinoconjunctivitis and protein contact dermatitis. Diagnosis of allergy to Anisakis relies on skin-prick tests and the detection of specific IgE by ImmunoCAP. Since Anisakis infests fish, fish allergy should be investigated in symptomatic patients. Anisakis proteins also demonstrate considerable immunological cross-reactivity to proteins of related nematodes and other invertebrates such as house-dust mites and cockroaches; this needs to be borne in mind when the diagnosis is made. This review outlines the approaches that have been used to increase the specificity of Anisakis diagnosis, including the use of immunoblotting and the identification of Anisakis allergens.

Item ID: 28332
Item Type: Article (Research - C1)
ISSN: 1609-3607
Funders: Medical Research Council of South Africa, National Research Foundation of South Africa, Allergy Society of South Africa research award
Date Deposited: 17 Jul 2013 09:27
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110701 Allergy @ 70%
11 MEDICAL AND HEALTH SCIENCES > 1101 Medical Biochemistry and Metabolomics > 110106 Medical Biochemistry: Proteins and Peptides (incl Medical Proteomics) @ 10%
11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111705 Environmental and Occupational Health and Safety @ 20%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 50%
92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920406 Food Safety @ 50%
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