The role of shellfish proteases in allergic diseases and inflammation

Sun, Shansun, and Lopata, Andreas L. (2010) The role of shellfish proteases in allergic diseases and inflammation. Current Allergy and Clinical Immunology, 23 (4). pp. 174-179.

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Proteases are well-known proteins involved in the enzymatic digestion of food but also in the regulation of blood coagulation and homeostasis. However, proteases also have allergenic potential and about 60 allergens are currently characterised from plant and animal sources. IgE-mediated allergic sensitisation to allergenic proteases is well characterised for inhaled allergens such as moulds, cockroaches and mites. However, there is growing evidence of non-IgE-mediated inflammation triggered by exogenous proteases via inhalation but also ingestion and skin contact. These proteases can activate a set of four distinct receptors (protease-activated receptors (PAR)), which are found on virtually all cells (mast cells, epithelium, eosinophils, neutrophils, monocytes-macrophages, lymphocytes, smooth muscle, endothelium, fibroblasts and neurons) involved in allergic reactions. This review outlines the different roles of proteases in allergic and inflammatory reactions. Preliminary data from our group demonstrate for the first time the presence of four types of proteases in rock lobster and two shrimp species. Trypsin-like activity seems to be the major enzyme action in all three shellfish species, with the highest proteolytic activity occurring under physiological conditions similar to those of the lung environment. This study is the foundation for further investigations into the role of proteases in allergic and inflammatory reactions towards exposure to shellfish allergens in the occupational and domestic environment.

Item ID: 28331
Item Type: Article (Research - C1)
ISSN: 1609-3607
Keywords: allergy, shellfish, proteases, Protease activation receptor
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Funders: Asthma Foundation Victoria
Date Deposited: 17 Jul 2013 09:27
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1101 Medical Biochemistry and Metabolomics > 110106 Medical Biochemistry: Proteins and Peptides (incl Medical Proteomics) @ 30%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110701 Allergy @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111705 Environmental and Occupational Health and Safety @ 20%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 80%
92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920406 Food Safety @ 20%
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