Bioactive cystine knot proteins

Daly, Norelle L., and Craik, David J. (2011) Bioactive cystine knot proteins. Current opinion in chemical biology, 15 (3). pp. 362-368.

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Abstract

The cystine knot is a structural motif that confers exceptional stability on proteins. Here we provide an update on the topology of the cystine knot and the combinatorial diversity of proteins that contain it. We describe recent chemical biology studies that have utilised this structural motif for the development of potential therapeutic or diagnostic agents. The cystine knot appears to have evolved in fungi, plants and animals as a stable and adaptable framework for the display of a wide variety of bioactive peptide sequences, but is amenable to chemical or recombinant synthesis and thus has a wide range of applications in chemistry, biology and medicine.

Item ID: 27035
Item Type: Article (Research - C1)
ISSN: 1879-0402
Funders: Australian Research Council (ARC)
Projects and Grants: DP0984390
Date Deposited: 23 May 2013 02:09
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1101 Medical Biochemistry and Metabolomics > 110106 Medical Biochemistry: Proteins and Peptides (incl Medical Proteomics) @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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