Albumins and their processing machinery are hijacked for cyclic peptides in sunflower

Mylne, Joshua S., Colgrave, Michelle L., Daly, Norelle, Chanson, Aurelie H., Elliott, Alysha G., McCallum, Emily J., Jones, Alun, and Craik, David J. (2011) Albumins and their processing machinery are hijacked for cyclic peptides in sunflower. Nature Chemical Biology, 7 (5). pp. 257-259.

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Abstract

The cyclic peptide sunflower trypsin inhibitor 1 (SFTI-1) blocks trypsin and is a promising drug lead and protein engineering scaffold. We show that SFTI-1 and the newfound SFT-L1 are buried within PawS1 and PawS2, precursors for seed storage protein albumins. Proalbumins are matured by asparaginyl endopeptidase, which we show is required to liberate both ends of SFTI-1 as well as to mature PawS1 albumin. Thus, these peptides emerge from within an albumin precursor by the action of albumin's own processing enzyme.

Item ID: 27030
Item Type: Article (Research - C1)
ISSN: 1552-4469
Date Deposited: 23 May 2013 02:43
FoR Codes: 06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060109 Proteomics and Intermolecular Interactions (excl Medical Proteomics) @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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