Epigenetics of stress

Collins, Andrew, Gutièrrez-Mecinas, María, Trollope, Alexandra F., and Reul, Johannes M.H.M. (2012) Epigenetics of stress. In: Párrizas, Marcelina, Gasa, Rosa, and Kaliman, Perla, (eds.) Epigenetics of Lifestyle. Bentham Science, Sharjah, Unites Arab Emirates, pp. 70-89.

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Abstract

Poor stress-coping is associated with a greater chance of developing a psychiatric illness such as post-traumatic stress disorder (PTSD) or depression. Lifestyle interventions which facilitate more appropriate responses to stress are much sought after. Exercise is one such intervention and is now commonly being prescribed as a cotreatment along with drugs for treating depression. Exercised rodents display reduced anxiety and impulsivity in a variety of behavioral paradigms. Rats exposed to psychological stress show differential epigenetic and gene expression mechanisms at the dentate gyrus (DG) after long-term voluntary exercise. Alterations within ERK MAPK signalling to chromatin seem to modulate the number of epigenetically marked neurons in the DG, improving cognitive responses to a stress-related event. Other lifestyle interventions such as nutrition or better maternal care in early life have been shown to induce changes at the epigenome which impact positively on mental health.

Item ID: 26847
Item Type: Book Chapter (Research - B1)
Keywords: stress, brain, hippocampus, learning, memory, chromatin, histone, exercise, glucocorticoid hormone, HPA axis, dentate gyrus, ERK MAPK, MSK1, immediate early gene, PTSD, anxiety, depression, cognition, adaptation, early life experience, DNA methylation, c-Fos, Egr-1, social defeat, CREB
ISBN: 978-1-60805-299-8
Date Deposited: 28 Nov 2014 01:49
FoR Codes: 17 PSYCHOLOGY AND COGNITIVE SCIENCES > 1702 Cognitive Science > 170205 Neurocognitive Patterns and Neural Networks @ 10%
06 BIOLOGICAL SCIENCES > 0604 Genetics > 060404 Epigenetics (incl Genome Methylation and Epigenomics) @ 90%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970117 Expanding Knowledge in Psychology and Cognitive Sciences @ 10%
97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 90%
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