Transforming growth factor-β and abdominal aortic aneurysms

Wang, Yutang, Krishna, Smriti, Walker, Phillip J., Norman, Paul, and Golledge, Jonathan (2013) Transforming growth factor-β and abdominal aortic aneurysms. Cardiovascular Pathology, 22 (2). pp. 126-132.

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Abdominal aortic aneurysms (AAAs) are common problems in aged people which can be associated with severe complications including aortic rupture and death. Transforming growth factor-beta (TGF beta) has been implicated as causative in the development of thoracic aortic aneurysms (TAAs). In contrast, current evidence suggests TGF beta inhibits AAA development. Polymorphisms in the TGF beta signaling components are associated with AAA in some human population studies. In experimental animals TGF beta protects against AAA formation, progression and rupture. In animal models of AAA TGF beta decreases aortic inflammatory cell infiltration, extracellular matrix degradation, and vascular smooth muscle cell apoptosis, all factors implicated in AAA pathogenesis. The TGF beta signaling pathway may provide a therapeutic target for AAA although better clarity is needed regarding the distinct roles of TGF beta in TAA and AAA.

Item ID: 26768
Item Type: Article (Research - C1)
ISSN: 1879-1336
Keywords: abdominal aortic aneurysm, extracellular matrix, matrix metalloproteinase, transforming growth factor-beta
Funders: National Health and Medical Research Council (NHMRC), BUPA Foundation
Projects and Grants: NHMRC 540404, NHMRC 1021416
Date Deposited: 24 Apr 2013 11:15
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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