Nonarchetypal Type II-like and atypical strains of Toxoplasma gondii infecting marsupials of Australia

Parameswaran, N., Thompson, R.C.A., Sundar, N., Pan, S., Johnson, M., Smith, N.C., and Grigg, M.E. (2010) Nonarchetypal Type II-like and atypical strains of Toxoplasma gondii infecting marsupials of Australia. International Journal for Parasitology, 40 (6). pp. 635-640.

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Abstract

Australia is geographically isolated and possesses a remarkable diversity of wildlife species. Marsupials are highly susceptible to infection with the cosmopolitan parasite Toxoplasma gondii. Of 46 marsupials screened for T. gondii by multilocus PCR-DNA sequencing at polymorphic genes (B1, SAG3, GRA6, GRA7), 12 were PCR-positive; the majority (67%; 9/12) were infected by non-archetypal Type II-like or atypical strains. Six novel alleles were detected at B1, indicating greater diversity of genotypes than previously envisaged. Two isolates lethal to marsupials, were avirulent to mice. The data support the conclusion that Australia’s isolation may have favoured the persistence of non-archetypal ancestral genotypes.

Item ID: 26370
Item Type: Article (Research - C1)
ISSN: 1879-0135
Funders: Australian Research Council, Department of Environment and Conservation in Western Australia, Intramural Research Program of the National Institutes of Health, National Institute of Allergy and Infectious Diseases
Date Deposited: 26 Apr 2013 05:26
FoR Codes: 07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070708 Veterinary Parasitology @ 60%
06 BIOLOGICAL SCIENCES > 0605 Microbiology > 060502 Infectious Agents @ 30%
11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 10%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 50%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 50%
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